June 2024
1. The Hedgehog (HH)-GLI2 pathway increases proliferation with loss of maturation in cardiomyocytes
Waldron et al. The HH-GLI2-CKSB1B network regulates the proliferation-to-maturation transition of cardiomyocytes. Stem Cells Translation Medicine, 2024
HH and GLI2 negatively regulates cardiomyocyte maturation by upregulating CKS1B. The GLI2 pathway is upregulated in patients with heart failure.
Chosen by Dr. Soichiro Ikeda