May 2024

1. Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism

Han et al. Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism. Nat Cell Biol 25: 1033-1046, 2023.

Long non-coding RNA LIPTER and MYH10-ACTIN cytoskeleton are involved in the transport of lipid droplets in the heart.

Chosen by Dr. Koichiro Takayama

2. ATF4 protects the heart from failure by antagonizing oxidative stress

Wang et al. ATF4 protects the heart from failure by antagonizing oxidative stress. Circ Res 131: 91-105, 2022.

ATF4 mediates the expression of antioxidants during heart failure.

Chosen by Dr. Risa Mukai

3. Inhibition of fatty acid oxidation enables heart regeneration in adult mice

Li et al. Inhibition of fatty acid oxidation enables heart regeneration in adult mice. Nature 622: 619-626, 2023.

Inhibition of fatty acid oxidation promotes cardiomyocyte proliferation in adult mouse heart through accumulation of alpha-ketoglutarate and KDM5-induced demethylation of H3K4me3 driving cardiomyocyte maturation. 

Chosen by Dr. Satvik Mareedu