August 2024

1. The role of plasminogen activator inhibitor 1 (PAI-1) in senescence

Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rbn pathway in fibrotic lung disease. Aging Cell, 2017

Synopsis: Serpin indicates “the serine proteinase inhibitor (serpin) superfamily”. Elevation of Serpine 1 (PAI-1) contributes to cell senescence of alveolar type 2 (ATII) in fibrotic lung disease.

Chosen by Dr. Yuka Watanabe

2. Cardiomyocyte secretome analysis

Secretome Analysis of Cardiomyocytes Identifies PCSK6 (Proprotein Convertase Subtilisin/Kexin Type 6) as a Novel Player in Cardiac Remodeling After Myocardial Infarction. Circulation, 2020

Synopsis: A novel mass spectrometry–based approach allows investigation of the secretome of primary cardiomyocytes.

Chosen by Dr. Takuma Takada