2010
145. Kuroda, J., Sadoshima, J. 2010.NADPH Oxidase and Cardiac Failure. J Cardiovasc Transl Res (in press)
144. Zablocki, D., Sadoshima, J. 2010. The one-two punch: knocking out angiotensin II in the heart. Journal of
Clinical Investigation. in press
143. Ago, T., Yang, Y., Zhai, P., Sadoshima, J. 2010. Nifedipine Inhibits Cardiac Hypertrophy and Left Venticular
Dyfunction in Response to Pressure Overload. J Cardiovascular Translational Research. in press
142. Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., Sadoshima, J. 2010. Upregulation of Nox4 by Hypertrophic Stimuli
Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes. Circ Res. Feb 25.
141. Chu, P.Y., Mariani, J., Finch, S., McMullen, J.R., Sadoshima, J., Marshall, T., Kaye, D.M. 2010. Bone Marrow-
Derived Cells Contribute of Fibrosis in the Chronically Failing Heart. Am J Pathol. Feb 11
2009
140. Hsu, C.P., Hariharan, N., Alcendor, R.N., Oka, S. and Sadoshima, J. 2009. Nicotinamide
phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophasy 5(8):1229-31.
139. Cho, J., Rameshwar, P. and Sadoshima, J. 2009. Distrinct Roles of GSK-3 and GSK-3β in Mediating
Cardiomyocyte Differentiation in Murine Bone Marrow Delived Mesenchymal Stem Cells. J. Biol. Chem. 284(52):36647-
58.
138. Hu, C.L., Chandra, R., Ge, H., Pain, J., Yan, L., Babu, G.J., Depre, D., Iwatsubo, K., Ishikawa, Y., Sadohsima,
J., Vatner, S.F., Vatner, D.F. 2009. Adenylyl Cyclase Type 5 Protein Expression during Cardiac Development and
Stress. Am J Physio Heart Circ Physiol. 297(5):H1776-82.
137. Woodcock, E.A., Grubb, D.R., Flitz, T.M., Marasco, S., Luo, J., McLeod-Dryden, T.J., Kaye, D.M., Sadoshima,
J., Du, X.J., Wong, C., McMullen, J.R., Dart, A.M. 2009 Selective Activation of the "B"splice Variant of Phospholipase
Cbeta1 in Chronically Dilated Human Mouse Atria. J Mol Cell Cardiol 47(5):676-83.
136. Gelpi, R.J., Gao, S., Zhai, P., Yan, L., Hong, C., Danridge, L.A., Ge, H., Maejima, Y., Donato, M., Yokota, M.,
Molkentin, J.D., Vatner, D.E., Vatner, S.F., Sadoshima, J. 2009 Genetic inhibition of calcineurin induces diastolic
dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol. 297(5):H1814-9.
135. Del Re, D.P., Sadoshima, J. 2009. Optimizing cell-based therapy for cardiac regeneration. Circulation. 120
(10):831-4.
134. Pretorius, L., Du, X.J., Woodcock, E.A,. Kiriazis,H., Lin, R.C., Marasco, S., Medcalf, R.L., Ming, Z., Head, G.A.,
Tan, J.W., Cemerlang, N., Sadoshima, J., Shioi, T., Izumo, S., Lukoshkova, E.V., Dart, A.M., Jennings,G.L., McMullen, J.
R. 2009. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am
J Pathol. 175(3):998-1009.
133. Hsu, C.P., Oka, S., Shao, D., Hariharan, N., Sadoshima, J. 2009. Nicotinamide phosphoribosyltransferase
regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 28;105(5):481-91.
132. Wu, C., Yan, L., Depre, C., Dhar, S.K., Shen, Y.T., Sadoshima, J., Vatner, S.F., Vatner, D.E. Cytochrome C
oxidase III as a mechanism for apoptosis in heart failure folloing myocardial infraction. Am J Physiol Cell Physiol. 297(4):
C928-34.
131. Bellis, A., Castaldo, D., Trimarco, V., Monti, M.G., Chivasso, P., Sadoshima, J., Trimarco, B., Morisco, C. 2009
Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late inschemic preconditioning.
Arterioscler Thromb Vasc Biol. 29(8):1207-12.
130. Yan, L., Sadoshima, J., Vatner, D.E., Vatner, S.F. 2009. Autophagy in ischemic preconditioning and
hibernating myocardium. Autophagy. 5(5):709-12.
129. Fu, C., Wu, C., Liu, T., Ago, T., Zhai, P., Sadoshima, J., Li, H. 2009. Elucidation of thioredoxin target protein
networks in mouse. Mol Cell Proteomics. 8(7):1674-87.
128. Oka, S., Ago, T., Kitazono,T., Zablocki, D., Sadoshima, J. 2009. The Role of Redox Modulation of Class II
Histone Deacetylases in Mediating Pathological Cardiac Hypertrophy. Journal of Molecular Medicine. 87(8):785-91.
127. Rane, S., He, M., Sayed, D., Vashistha, H., Malhotra, A., Sadoshima, J., Vatner, D.E., Vatner, S.F., Adbellatif,
M. 2009. Downregulation of MiR-199a Depresses Hypoxia-Inducible Factor-1{alpha} and Sirtuin 1 and Recapitulates
Hypoxia Preconditioning in Cardiac Myocytes. Circ Res. 104(7):879-86
126. Nishida, K., Kyoi, S., Yamaguchi, O., Sadoshima, J., Otsu, K. 2009. The role of autophagy in the heart. Cell
Death Differ. 16(1):31-38.
125. Perry, C.N., Kyoi, S., Hariharan, N., Takagi, H., Sadoshima, J., Gottlieb, R.A. 2009. Novel methods for
measuring cardiac autophagy in vivo. Methods in Enzymology. 453:325-342.
124. Vatner, F.S., Yan, L., Ishikawa, Y., Vatner, E.D., and Sadoshima, J. 2009. Adenylyl Cyclase Type 5 Disruption
Prolongs Longivity and Protects the Heart against Stress. Circ.J. 73(2):195-200.
2008
123. Ago, T., Liu, T., Zhai, P., Chen, W., Li, H., Molkentin, J.D., Vatner, S.F., and Sadoshima, J. 2008. A redox-
dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 133:978-993.
122. Fu, C., Hu, J., Liu, T., Ago, T., Sadoshima, J., and Li, H. 2008. Quantitative analysis of redox-sensitive
proteome with DIGE and ICAT. J Proteome Res 7:3789-3802.
121. Hsu, C.P., Odewale, I., Alcendor, R.R., and Sadoshima, J. 2008. Sirt1 protects the heart from aging and
stress. Biol Chem 389:221-231.
120. Klionsky, D.J., Abeliovich, H., Agostinis, P. et al (JS is 168th out of 236 authors) 2008. Guidelines for the use
and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.
119. Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto H, Takagi H, Tamamoti-Adachi T, Kitajima S,
Sadoshima J. Phosphorylation of GSK-3 is essential for myocyte proliferation in the heart under pressure overload.
Proc Natl Acad Sci U S A. 2008; 105: 20900-20905.
118. Matsui, Y., Kyoi, S., Takagi, H., Hsu, C.P., Hariharan, N., Ago, T., Vatner, S.F., and Sadoshima, J. 2008.
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion.
Autophagy 4:409-415.
117. Matsui, Y., Nakano, N., Shao, D., Gao, S., Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., Tao, W.,
Wagner, T., Nojima, H., and Sadoshima, J. 2008. Lats2 is a negative regulator of myocyte size in the heart. Circ Res
103:1309-1318.
116. Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., and Sunagawa, K. 2008.
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.
Arterioscler Thromb Vasc Biol 28:1263-1269.
115. Morisco, C., Marrone, C., Galeotti, J., Shao, D., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2008.
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac
myocytes. Cardiovasc Res 78:36-44.
114. Nishida, K., Kyoi, S., Yamaguchi, O., Sadoshima, J., and Otsu, K. 2008. The role of autophagy in the heart.
Cell Death Differ.
113. Ohtsubo, H., Ichiki, T., Imayama, I., Ono, H., Fukuyama, K., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K.
2008. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells. Biochem Biophys Res
Commun 367:474-480.
112. Sadoshima, J. 2008. The role of autophagy during ischemia/reperfusion. Autophagy 4:402-403.
111. Shen, Y.T., Depre, C., Yan, L., Park, J.Y., Tian, B., Jain, K., Chen, L., Zhang, Y., Kudej, R.K., Zhao, X.,
Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2008. Repetitive ischemia by coronary stenosis induces a novel window
of ischemic preconditioning. Circulation 118:1961-1969.
110. Zhai, P., and Sadoshima, J. 2008. Overcoming an energy crisis?: an adaptive role of glycogen synthase
kinase-3 inhibition in ischemia/reperfusion. Circ Res 103:910-913.
2007
109. Ago, T., and Sadoshima, J. 2007. Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid
Redox Signal 9:679-687.
108. Alcendor, R.R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S.F., and
Sadoshima, J. 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100:1512-1521.
107. Hirotani, S., Zhai, P., Tomita, H., Galeotti, J., Marquez, J.P., Gao, S., Hong, C., Yatani, A., Avila, J., and
Sadoshima, J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 101:1164-
1174.
106. Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., and Sadoshima, J. 2007.
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and
Beclin 1 in mediating autophagy. Circ Res 100:914-922.
105. Morisco, C., Marrone, C., Trimarco, V., Crispo, S., Monti, M.G., Sadoshima, J., and Trimarco, B. 2007. Insulin
resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1
expression. Cardiovasc Res 76:453-464.
104. Nishizawa, T., Shen, Y.T., Rossi, F., Hong, C., Robbins, J., Ishikawa, Y., Sadoshima, J., Vatner, D.E., and
Vatner, S.F. 2007. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am
J Physiol Heart Circ Physiol 292:H971-975.
103. Odashima, M., Usui, S., Takagi, H., Hong, C., Liu, J., Yokota, M., and Sadoshima, J. 2007. Inhibition of
endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial
infarction. Circ Res 100:1344-1352.
102. Ohtsubo, H., Ichiki, T., Miyazaki, R., Inanaga, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa,
K. 2007. Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell. Arterioscler Thromb Vasc Biol
27:1549-1555.
101. Peter, P.S., Brady, J.E., Yan, L., Chen, W., Engelhardt, S., Wang, Y., Sadoshima, J., Vatner, S.F., and Vatner,
D.E. 2007. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic
receptor, but not beta 1-adrenergic receptor. J Clin Invest 117:1335-1343.]
100. Takagi, H., Matsui, Y., Hirotani, S., Sakoda, H., Asano, T., and Sadoshima, J. 2007. AMPK mediates
autophagy during myocardial ischemia in vivo. Autophagy 3:405-407.
99. Takagi, H., Matsui, Y., and Sadoshima, J. 2007. The role of autophagy in mediating cell survival and death
during ischemia and reperfusion in the heart. Antioxid Redox Signal 9:1373-1381.
98. Yan, L., Vatner, D.E., O'Connor, J.P., Ivessa, A., Ge, H., Chen, W., Hirotani, S., Ishikawa, Y., Sadoshima, J.,
and Vatner, S.F. 2007. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130:
247-258.
97. Zhai, P., Gao, S., Holle, E., Yu, X., Yatani, A., Wagner, T., and Sadoshima, J. 2007. Glycogen synthase kinase-
3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-
regulated kinases. J Biol Chem 282:33181-33191.
2006
96. Ago, T., and Sadoshima, J. 2006. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res 98:294-
297.
95. Ago, T., and Sadoshima, J. 2006. Thioredoxin and ventricular remodeling. J Mol Cell Cardiol 41:762-773.
94. Ago, T., Yeh, I., Yamamoto, M., Schinke-Braun, M., Brown, J.A., Tian, B., and Sadoshima, J. 2006.
Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart.
Antioxid Redox Signal 8:1635-1650.
93. Chen, I.Y., Lypowy, J., Pain, J., Sayed, D., Grinberg, S., Alcendor, R.R., Sadoshima, J., and Abdellatif, M. 2006.
Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol
Chem 281:19369-19377.
92. Depre, C., Wang, Q., Yan, L., Hedhli, N., Peter, P., Chen, L., Hong, C., Hittinger, L., Ghaleh, B., Sadoshima, J.,
Vatner, D.E., Vatner, S.F., and Madura, K. 2006. Activation of the cardiac proteasome during pressure overload
promotes ventricular hypertrophy. Circulation 114:1821-1828.
91. Liu, J., Sadoshima, J., Zhai, P., Hong, C., Yang, G., Chen, W., Yan, L., Wang, Y., Vatner, S.F., and Vatner, D.
E. 2006. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. J
Mol Cell Cardiol 41:680-688.
90. Nishizawa, T., Vatner, S.F., Hong, C., Shen, Y.T., Hardt, S.E., Robbins, J., Ishikawa, Y., Sadoshima, J., and
Vatner, D.E. 2006. Overexpressed cardiac Gsalpha in rabbits. J Mol Cell Cardiol 41:44-50.
89. Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J.
T., Puigserver, P., Sadoshima, J., Deng, H., Pedrini, S., Gandy, S., Sauve, A.A., and Pasinetti, G.M. 2006. Neuronal
SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by
calorie restriction. J Biol Chem 281:21745-21754.
88. Sadoshima, J. 2006. Redox regulation of growth and death in cardiac myocytes. Antioxid Redox Signal 8:1621-
1624.
87. Usui, S., Yeh, I., Tian, B., and Sadoshima, J. 2006. Global changes in gene expression during cardiac
hypertrophy: a new direction of cardiac signaling research. J Mol Cell Cardiol 41:219-222.
86. Yan, L., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2006. Autophagy: a novel protective mechanism in
chronic ischemia. Cell Cycle 5:1175-1177.
85. Zebrowski, D.C., Alcendor, R.R., Kirshenbaum, L.A., and Sadoshima, J. 2006. Caspase-3 mediated cleavage
of MEKK1 promotes p53 transcriptional activity. J Mol Cell Cardiol 40:605-618.
84. Zhai, P., Galeotti, J., Liu, J., Holle, E., Yu, X., Wagner, T., and Sadoshima, J. 2006. An angiotensin II type 1
receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated
cardiac hypertrophy. Circ Res 99:528-536.
83. Zhai P, Galeotti J, Sadoshima J. 2006. Unconventional signaling mechanisms mediated by the angiotensin II
type I receptor in cardiovascular cell types. High Blood Pressure and Cardiovasc Prevention: 13, 143-150.
2005
82. Ding, B., Abe, J., Wei, H., Huang, Q., Walsh, R.A., Molina, C.A., Zhao, A., Sadoshima, J., Blaxall, B.C., Berk, B.
C., and Yan, C. 2005. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.
Circulation 111:2469-2476.
81. Ding, B., Abe, J., Wei, H., Xu, H., Che, W., Aizawa, T., Liu, W., Molina, C.A., Sadoshima, J., Blaxall, B.C., Berk,
B.C., and Yan, C. 2005. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor
(ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A 102:14771-14776.
80. Hase, M., Depre, C., Vatner, S.F., and Sadoshima, J. 2005. H11 has dose-dependent and dual hypertrophic
and proapoptotic functions in cardiac myocytes. Biochem J 388:475-483.
79. Hirotani, S., and Sadoshima, J. 2005. Preconditioning effects of PKCdelta. J Mol Cell Cardiol 39:719-721.
78. Morisco, C., Condorelli, G., Trimarco, V., Bellis, A., Marrone, C., Condorelli, G., Sadoshima, J., and Trimarco,
B. 2005. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ
Res 96:180-188.
77. Ono, H., Ichiki, T., Ohtsubo, H., Fukuyama, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K.
2005. Critical role of Mst1 in vascular remodeling after injury. Arterioscler Thromb Vasc Biol 25:1871-1876.
76. Yan, L., Vatner, D.E., Kim, S.J., Ge, H., Masurekar, M., Massover, W.H., Yang, G., Matsui, Y., Sadoshima, J.,
and Vatner, S.F. 2005. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A 102:13807-13812.
75. Zhai, P., Yamamoto, M., Galeotti, J., Liu, J., Masurekar, M., Thaisz, J., Irie, K., Holle, E., Yu, X., Kupershmidt, S.,
Roden, D.M., Wagner, T., Yatani, A., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2005. Cardiac-specific
overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in
transgenic mice. J Clin Invest 115:3045-3056.
2004
74. Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., and Sadoshima, J. 2004. Silent information regulator
2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac
myocytes. Circ Res 95:971-980.
73. Hardt, S.E., and Sadoshima, J. 2004. Negative regulators of cardiac hypertrophy. Cardiovasc Res 63:500-509.
72. Hardt, S.E., Tomita, H., Katus, H.A., and Sadoshima, J. 2004. Phosphorylation of eukaryotic translation
initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.
Circ Res 94:926-935.
71. Karoor, V., Vatner, S.F., Takagi, G., Yang, G., Thaisz, J., Sadoshima, J., and Vatner, D.E. 2004. Propranolol
prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart
failure. J Mol Cell Cardiol 36:305-312.
70. Kawabe, J., Okumura, S., Lee, M.C., Sadoshima, J., and Ishikawa, Y. 2004. Translocation of caveolin regulates
stretch-induced ERK activity in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 286:H1845-1852.
69. Kim, T.G., Chen, J., Sadoshima, J., and Lee, Y. 2004. Jumonji represses atrial natriuretic factor gene
expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol 24:10151-10160.
68. Matsui, Y., and Sadoshima, J. 2004. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli:
implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol 37:477-481.
2003
67. Kim, S.J., Peppas, A., Hong, S.K., Yang, G., Huang, Y., Diaz, G., Sadoshima, J., Vatner, D.E., and Vatner, S.F.
2003. Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circ
Res 92:1233-1239.
65. Kim, Y.K., Kim, S.J., Yatani, A., Huang, Y., Castelli, G., Vatner, D.E., Liu, J., Zhang, Q., Diaz, G., Zieba, R.,
Thaisz, J., Drusco, A., Croce, C., Sadoshima, J., Condorelli, G., and Vatner, S.F. 2003. Mechanism of enhanced
cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem 278:47622-47628.
65. Li, J., Yatani, A., Kim, S.J., Takagi, G., Irie, K., Zhang, Q., Karoor, V., Hong, C., Yang, G., Sadoshima, J.,
Depre, C., Vatner, D.E., West, M.J., and Vatner, S.F. 2003. Neurally-mediated increase in calcineurin activity regulates
cardiac contractile function in absence of hypertrophy. Cardiovasc Res 59:649-657.
43. Morisco, C., Sadoshima, J., Trimarco, B., Arora, R., Vatner, D.E., and Vatner, S.F. 2003. Is treating cardiac
hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol 284:H1043-1047.
63. Okumura, S., Kawabe, J., Yatani, A., Takagi, G., Lee, M.C., Hong, C., Liu, J., Takagi, I., Sadoshima, J., Vatner,
D.E., Vatner, S.F., and Ishikawa, Y. 2003. Type 5 adenylyl cyclase disruption alters not only sympathetic but also
parasympathetic and calcium-mediated cardiac regulation. Circ Res 93:364-371.
62. Okumura, S., Takagi, G., Kawabe, J., Yang, G., Lee, M.C., Hong, C., Liu, J., Vatner, D.E., Sadoshima, J.,
Vatner, S.F., and Ishikawa, Y. 2003. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against
pressure overload. Proc Natl Acad Sci U S A 100:9986-9990.
61. Seta, K., and Sadoshima, J. 2003. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor
mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem 278:9019-9026.
60. Tomita, H., Nazmy, M., Kajimoto, K., Yehia, G., Molina, C.A., and Sadoshima, J. 2003. Inducible cAMP early
repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac
myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circ Res 93:12-22.
59. Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T., Vatner, S.F., and Sadoshima, J. 2003.
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest 112:
1395-1406.
58. Yamamoto, S., Yang, G., Zablocki, D., Liu, J., Hong, C., Kim, S.J., Soler, S., Odashima, M., Thaisz, J., Yehia,
G., Molina, C.A., Yatani, A., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2003. Activation of Mst1 causes dilated
cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest 111:
1463-1474.
2002
57. Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Russo, M.A., Gu, Y., Dalton,
N., Chung, C., Latronico, M.V., Napoli, C., Sadoshima, J., Croce, C.M., and Ross, J., Jr. 2002. Akt induces enhanced
myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A 99:12333-12338.
56. Depre, C., Hase, M., Gaussin, V., Zajac, A., Wang, L., Hittinger, L., Ghaleh, B., Yu, X., Kudej, R.K., Wagner, T.,
Sadoshima, J., and Vatner, S.F. 2002. H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circ Res 91:
1007-1014.
54. Hardt, S.E., and Sadoshima, J. 2002. Glycogen synthase kinase-3beta: a novel regulator of cardiac
hypertrophy and development. Circ Res 90:1055-1063.
54. Sadoshima, J. 2002. Novel AT(1) receptor-independent functions of losartan. Circ Res 90:754-756.
53. Sadoshima, J., Montagne, O., Wang, Q., Yang, G., Warden, J., Liu, J., Takagi, G., Karoor, V., Hong, C.,
Johnson, G.L., Vatner, D.E., and Vatner, S.F. 2002. The MEKK1-JNK pathway plays a protective role in pressure
overload but does not mediate cardiac hypertrophy. J Clin Invest 110:271-279.
52. Seta, K., Nanamori, M., Modrall, J.G., Neubig, R.R., and Sadoshima, J. 2002. AT1 receptor mutant lacking
heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol
Chem 277:9268-9277.
51. Seta, K., and Sadoshima, J. 2002. What is the unique function of SAPK3/p38gamma in cardiac myocytes? J
Mol Cell Cardiol 34:597-600.
2001
50. Modrall, J.G., Nanamori, M., Sadoshima, J., Barnhart, D.C., Stanley, J.C., and Neubig, R.R. 2001. ANG II type 1
receptor downregulation does not require receptor endocytosis or G protein coupling. Am J Physiol Cell Physiol 281:
C801-809.
49. Morisco, C., Seta, K., Hardt, S.E., Lee, Y., Vatner, S.F., and Sadoshima, J. 2001. Glycogen synthase kinase
3beta regulates GATA4 in cardiac myocytes. J Biol Chem 276:28586-28597.
48. Morisco, C., Zebrowski, D.C., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2001. Beta-adrenergic cardiac
hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol 33:561-573.
47. Yamamoto, S., Seta, K., Morisco, C., Vatner, S.F., and Sadoshima, J. 2001. Chelerythrine rapidly induces
apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol 33:1829-1848.
46. Yang, G., Meguro, T., Hong, C., Asai, K., Takagi, G., Karoor, V.L., Sadoshima, J., Vatner, D.E., Bishop, S.P.,
and Vatner, S.F. 2001. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be
due to apoptosis and fibrosis. J Mol Cell Cardiol 33:1505-1514.
2000
45. Aoki, H., Richmond, M., Izumo, S., and Sadoshima, J. 2000. Specific role of the extracellular signal-regulated
kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J 347 Pt 1:275-284.
44. Aoki, H., Sadoshima, J., and Izumo, S. 2000. Myosin light chain kinase mediates sarcomere organization during
cardiac hypertrophy in vitro. Nat Med 6:183-188.
43. Babu, G.J., Lalli, M.J., Sussman, M.A., Sadoshima, J., and Periasamy, M. 2000. Phosphorylation of elk-1 by
MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol 32:
1447-1457.
42. Morisco, C., Zebrowski, D., Condorelli, G., Tsichlis, P., Vatner, S.F., and Sadoshima, J. 2000. The Akt-glycogen
synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor
stimulation in cardiac myocytes. J Biol Chem 275:14466-14475.
41. Sadoshima, J. 2000. Cytokine actions of angiotensin II. Circ Res 86:1187-1189.
1999
40. Malhotra, R., Sadoshima, J., Brosius, F.C., 3rd, and Izumo, S. 1999. Mechanical stretch and angiotensin II
differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circ Res 85:137-146.
39. Yamamoto, M., Okumura, S., Schwencke, C., Sadoshima, J., and Ishikawa, Y. 1999. High efficiency gene
transfer by multiple transfection protocol. Histochem J 31:241-243.
1998
38. Aoki, H., Izumo, S., and Sadoshima, J. 1998. Angiotensin II activates RhoA in cardiac myocytes: a critical role of
RhoA in angiotensin II-induced premyofibril formation. Circ Res 82:666-676.
37. Sadoshima, J. 1998. Versatility of the angiotensin II type 1 receptor. Circ Res 82:1352-1355.
1997
36. Sadoshima, J., Aoki, H., and Izumo, S. 1997. Angiotensin II and serum differentially regulate expression of
cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac
myocytes. Circ Res 80:228-241.
35. Sadoshima, J., and Izumo, S. 1997. The cellular and molecular response of cardiac myocytes to mechanical
stress. Annu Rev Physiol 59:551-571.
34. Sadoshima, J., and Izumo, S. 1997. Tyrosine kinases mediation of c-fos expression by cell swelling in cardiac
myocytes. Heart Vessels Suppl 12:194-197.
33. Todisco, A., Takeuchi, Y., Yamada, J., Sadoshima, J.I., and Yamada, T. 1997. Molecular mechanisms for
somatostatin inhibition of c-fos gene expression. Am J Physiol 272:G721-726.
1996
32. Jahn, L., Sadoshima, J., Greene, A., Parker, C., Morgan, K.G., and Izumo, S. 1996. Conditional differentiation
of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. J Cell Sci
109 ( Pt 2):397-407.
31. Sadoshima, J., and Izumo, S. 1996. Autocrine secretion of angiotensin II mediates stretch-induced hypertrophy
of cardiac myocytes in vitro. Contrib Nephrol 118:214-221.
30. Sadoshima, J., and Izumo, S. 1996. The heterotrimeric G q protein-coupled angiotensin II receptor activates
p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. Embo J 15:775-787.
29. Sadoshima, J., Malhotra, R., and Izumo, S. 1996. The role of the cardiac renin-angiotensin system in load-
induced cardiac hypertrophy. J Card Fail 2:S1-6.
28. Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1996. Tyrosine kinase activation is an immediate and
essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes. Embo J
15:5535-5546.
1995
27. Sadoshima, J., and Izumo, S. 1995. Rapamycin selectively inhibits angiotensin II-induced increase in protein
synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy.
Circ Res 77:1040-1052.
26. Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1995. Angiotensin II and other hypertrophic stimuli
mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6
kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circ Res 76:1-15.
25. Schunkert, H., Sadoshima, J., Cornelius, T., Kagaya, Y., Weinberg, E.O., Izumo, S., Riegger, G., and Lorell, B.
H. 1995. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction
of cardiac protein synthesis by angiotensin II. Circ Res 76:489-497.
1994
24. Jahn, L., Sadoshima, J., and Izumo, S. 1994. Cyclins and cyclin-dependent kinases are differentially regulated
during terminal differentiation of C2C12 muscle cells. Exp Cell Res 212:297-307.
23. Kai, H., Koyanagi, S., Hirooka, Y., Sugimachi, M., Sadoshima, J., Suzuki, S., and Takeshita, A. 1994. Right-to-
left shunt across atrial septal defect related to tricuspid regurgitation: assessment by transesophageal Doppler
echocardiography. Am Heart J 127:578-584.
1993
22. Sadoshima, J., and Izumo, S. 1993. Mechanotransduction in stretch-induced hypertrophy of cardiac myocytes.
J Recept Res 13:777-794.
21. Sadoshima, J., and Izumo, S. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways
in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. Embo J 12:1681-1692.
20. Sadoshima, J., and Izumo, S. 1993. Molecular characterization of angiotensin II--induced hypertrophy of
cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73:413-423.
19. Sadoshima, J., and Izumo, S. 1993. Signal transduction pathways of angiotensin II--induced c-fos gene
expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res 73:424-438.
18. Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-
induced hypertrophy of cardiac myocytes in vitro. Cell 75:977-984.
1992
17. Sadoshima, J., Jahn, L., Takahashi, T., Kulik, T.J., and Izumo, S. 1992. Molecular characterization of the
stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem
267:10551-10560.
16. Sadoshima, J., Koyanagi, S., Sugimachi, M., Hirooka, Y., and Takeshita, A. 1992. Evaluation of the severity of
mitral regurgitation by transesophageal Doppler flow echocardiography. Am Heart J 123:1245-1251.
15. Sadoshima, J., Takahashi, T., Jahn, L., and Izumo, S. 1992. Roles of mechano-sensitive ion channels,
cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac
myocytes. Proc Natl Acad Sci U S A 89:9905-9909.
1991
14. Lai, C.P., Koyanagi, S., Sadoshima, J., Takeshita, A., and Tokunaga, K. 1991. Transesophageal
echocardiographic findings of quadricuspid aortic valve. Jpn Heart J 32:731-734.
13. Sadoshima, J., and Akaike, N. 1991. Kinetic properties of the caffeine-induced transient outward current in bull-
frog sympathetic neurones. J Physiol 433:341-355.
1990
12. Kuga, T., Sadoshima, J., Tomoike, H., Kanaide, H., Akaike, N., and Nakamura, M. 1990. Actions of Ca2+
antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res 67:469-480.
11. Sadoshima, J., Oyama, Y., and Akaike, N. 1990. Inhibition of nicotinic acetylcholine response by atropine in
frog isolated sympathetic neurons. Brain Res 508:147-151.
1989
10. Akaike, N., Kanaide, H., Kuga, T., Nakamura, M., Sadoshima, J., and Tomoike, H. 1989. Low-voltage-activated
calcium current in rat aorta smooth muscle cells in primary culture. J Physiol 416:141-160.
9. Akaike, N., and Sadoshima, J. 1989. Caffeine affects four different ionic currents in the bull-frog sympathetic
neurone. J Physiol 412:221-244.
8. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1989. Voltage-dependent anion-
selective channels in cultured smooth muscle cells of the rat aorta. Comp Biochem Physiol A Comp Physiol 92:61-63.
1988
7. Oyama, Y., Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Some properties of inhibitory action of lidocaine
on the Ca2+ current of single isolated frog sensory neurons. Brain Res 442:223-228.
6. Sadoshima, J., Akaike, N., Kanaide, H., and Nakamura, M. 1988. Cyclic AMP modulates Ca-activated K channel
in cultured smooth muscle cells of rat aortas. Am J Physiol 255:H754-759.
5. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1988. Ca-activated K channel in
cultured smooth muscle cells of rat aortic media. Am J Physiol 255:H410-418.
4. Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Effects of neostigmine and physostigmine on the
acetylcholine receptor-ionophore complex in frog isolated sympathetic neurones. Br J Pharmacol 94:620-624.
1987
3. Inoue, M., Sadoshima, J., and Akaike, N. 1987. Different actions of intracellular free calcium on resting and
GABA-gated chloride conductances. Brain Res 404:301-303.
2. Sadoshima, J., Nakashima, Y., Taira, Y., Koyanagi, S., Takeshita, A., Tanaka, K., and Nakamura, M. 1987. A
case of primary dissecting aneurysm of the coronary artery. Jpn Heart J 28:799-804.
1. Sadoshima, J., Taira, Y., Shimokawa, H., Koyanagi, S., Takeshita, A., and Nakamura, M. 1987. Two cases of
dilated cardiomyopathy complicated by left ventricular aneurysm. Chest 92:377-379.
145. Kuroda, J., Sadoshima, J. 2010.NADPH Oxidase and Cardiac Failure. J Cardiovasc Transl Res (in press)
144. Zablocki, D., Sadoshima, J. 2010. The one-two punch: knocking out angiotensin II in the heart. Journal of
Clinical Investigation. in press
143. Ago, T., Yang, Y., Zhai, P., Sadoshima, J. 2010. Nifedipine Inhibits Cardiac Hypertrophy and Left Venticular
Dyfunction in Response to Pressure Overload. J Cardiovascular Translational Research. in press
142. Ago, T., Kuroda, J., Pain, J., Fu, C., Li, H., Sadoshima, J. 2010. Upregulation of Nox4 by Hypertrophic Stimuli
Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac Myocytes. Circ Res. Feb 25.
141. Chu, P.Y., Mariani, J., Finch, S., McMullen, J.R., Sadoshima, J., Marshall, T., Kaye, D.M. 2010. Bone Marrow-
Derived Cells Contribute of Fibrosis in the Chronically Failing Heart. Am J Pathol. Feb 11
2009
140. Hsu, C.P., Hariharan, N., Alcendor, R.N., Oka, S. and Sadoshima, J. 2009. Nicotinamide
phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophasy 5(8):1229-31.
139. Cho, J., Rameshwar, P. and Sadoshima, J. 2009. Distrinct Roles of GSK-3 and GSK-3β in Mediating
Cardiomyocyte Differentiation in Murine Bone Marrow Delived Mesenchymal Stem Cells. J. Biol. Chem. 284(52):36647-
58.
138. Hu, C.L., Chandra, R., Ge, H., Pain, J., Yan, L., Babu, G.J., Depre, D., Iwatsubo, K., Ishikawa, Y., Sadohsima,
J., Vatner, S.F., Vatner, D.F. 2009. Adenylyl Cyclase Type 5 Protein Expression during Cardiac Development and
Stress. Am J Physio Heart Circ Physiol. 297(5):H1776-82.
137. Woodcock, E.A., Grubb, D.R., Flitz, T.M., Marasco, S., Luo, J., McLeod-Dryden, T.J., Kaye, D.M., Sadoshima,
J., Du, X.J., Wong, C., McMullen, J.R., Dart, A.M. 2009 Selective Activation of the "B"splice Variant of Phospholipase
Cbeta1 in Chronically Dilated Human Mouse Atria. J Mol Cell Cardiol 47(5):676-83.
136. Gelpi, R.J., Gao, S., Zhai, P., Yan, L., Hong, C., Danridge, L.A., Ge, H., Maejima, Y., Donato, M., Yokota, M.,
Molkentin, J.D., Vatner, D.E., Vatner, S.F., Sadoshima, J. 2009 Genetic inhibition of calcineurin induces diastolic
dysfunction in mice with chronic pressure overload. Am J Physiol Heart Circ Physiol. 297(5):H1814-9.
135. Del Re, D.P., Sadoshima, J. 2009. Optimizing cell-based therapy for cardiac regeneration. Circulation. 120
(10):831-4.
134. Pretorius, L., Du, X.J., Woodcock, E.A,. Kiriazis,H., Lin, R.C., Marasco, S., Medcalf, R.L., Ming, Z., Head, G.A.,
Tan, J.W., Cemerlang, N., Sadoshima, J., Shioi, T., Izumo, S., Lukoshkova, E.V., Dart, A.M., Jennings,G.L., McMullen, J.
R. 2009. Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation. Am
J Pathol. 175(3):998-1009.
133. Hsu, C.P., Oka, S., Shao, D., Hariharan, N., Sadoshima, J. 2009. Nicotinamide phosphoribosyltransferase
regulates cell survival through NAD+ synthesis in cardiac myocytes. Circ Res. 28;105(5):481-91.
132. Wu, C., Yan, L., Depre, C., Dhar, S.K., Shen, Y.T., Sadoshima, J., Vatner, S.F., Vatner, D.E. Cytochrome C
oxidase III as a mechanism for apoptosis in heart failure folloing myocardial infraction. Am J Physiol Cell Physiol. 297(4):
C928-34.
131. Bellis, A., Castaldo, D., Trimarco, V., Monti, M.G., Chivasso, P., Sadoshima, J., Trimarco, B., Morisco, C. 2009
Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late inschemic preconditioning.
Arterioscler Thromb Vasc Biol. 29(8):1207-12.
130. Yan, L., Sadoshima, J., Vatner, D.E., Vatner, S.F. 2009. Autophagy in ischemic preconditioning and
hibernating myocardium. Autophagy. 5(5):709-12.
129. Fu, C., Wu, C., Liu, T., Ago, T., Zhai, P., Sadoshima, J., Li, H. 2009. Elucidation of thioredoxin target protein
networks in mouse. Mol Cell Proteomics. 8(7):1674-87.
128. Oka, S., Ago, T., Kitazono,T., Zablocki, D., Sadoshima, J. 2009. The Role of Redox Modulation of Class II
Histone Deacetylases in Mediating Pathological Cardiac Hypertrophy. Journal of Molecular Medicine. 87(8):785-91.
127. Rane, S., He, M., Sayed, D., Vashistha, H., Malhotra, A., Sadoshima, J., Vatner, D.E., Vatner, S.F., Adbellatif,
M. 2009. Downregulation of MiR-199a Depresses Hypoxia-Inducible Factor-1{alpha} and Sirtuin 1 and Recapitulates
Hypoxia Preconditioning in Cardiac Myocytes. Circ Res. 104(7):879-86
126. Nishida, K., Kyoi, S., Yamaguchi, O., Sadoshima, J., Otsu, K. 2009. The role of autophagy in the heart. Cell
Death Differ. 16(1):31-38.
125. Perry, C.N., Kyoi, S., Hariharan, N., Takagi, H., Sadoshima, J., Gottlieb, R.A. 2009. Novel methods for
measuring cardiac autophagy in vivo. Methods in Enzymology. 453:325-342.
124. Vatner, F.S., Yan, L., Ishikawa, Y., Vatner, E.D., and Sadoshima, J. 2009. Adenylyl Cyclase Type 5 Disruption
Prolongs Longivity and Protects the Heart against Stress. Circ.J. 73(2):195-200.
2008
123. Ago, T., Liu, T., Zhai, P., Chen, W., Li, H., Molkentin, J.D., Vatner, S.F., and Sadoshima, J. 2008. A redox-
dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell 133:978-993.
122. Fu, C., Hu, J., Liu, T., Ago, T., Sadoshima, J., and Li, H. 2008. Quantitative analysis of redox-sensitive
proteome with DIGE and ICAT. J Proteome Res 7:3789-3802.
121. Hsu, C.P., Odewale, I., Alcendor, R.R., and Sadoshima, J. 2008. Sirt1 protects the heart from aging and
stress. Biol Chem 389:221-231.
120. Klionsky, D.J., Abeliovich, H., Agostinis, P. et al (JS is 168th out of 236 authors) 2008. Guidelines for the use
and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.
119. Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto H, Takagi H, Tamamoti-Adachi T, Kitajima S,
Sadoshima J. Phosphorylation of GSK-3 is essential for myocyte proliferation in the heart under pressure overload.
Proc Natl Acad Sci U S A. 2008; 105: 20900-20905.
118. Matsui, Y., Kyoi, S., Takagi, H., Hsu, C.P., Hariharan, N., Ago, T., Vatner, S.F., and Sadoshima, J. 2008.
Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion.
Autophagy 4:409-415.
117. Matsui, Y., Nakano, N., Shao, D., Gao, S., Luo, W., Hong, C., Zhai, P., Holle, E., Yu, X., Yabuta, N., Tao, W.,
Wagner, T., Nojima, H., and Sadoshima, J. 2008. Lats2 is a negative regulator of myocyte size in the heart. Circ Res
103:1309-1318.
116. Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., and Sunagawa, K. 2008.
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.
Arterioscler Thromb Vasc Biol 28:1263-1269.
115. Morisco, C., Marrone, C., Galeotti, J., Shao, D., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2008.
Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac
myocytes. Cardiovasc Res 78:36-44.
114. Nishida, K., Kyoi, S., Yamaguchi, O., Sadoshima, J., and Otsu, K. 2008. The role of autophagy in the heart.
Cell Death Differ.
113. Ohtsubo, H., Ichiki, T., Imayama, I., Ono, H., Fukuyama, K., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K.
2008. Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells. Biochem Biophys Res
Commun 367:474-480.
112. Sadoshima, J. 2008. The role of autophagy during ischemia/reperfusion. Autophagy 4:402-403.
111. Shen, Y.T., Depre, C., Yan, L., Park, J.Y., Tian, B., Jain, K., Chen, L., Zhang, Y., Kudej, R.K., Zhao, X.,
Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2008. Repetitive ischemia by coronary stenosis induces a novel window
of ischemic preconditioning. Circulation 118:1961-1969.
110. Zhai, P., and Sadoshima, J. 2008. Overcoming an energy crisis?: an adaptive role of glycogen synthase
kinase-3 inhibition in ischemia/reperfusion. Circ Res 103:910-913.
2007
109. Ago, T., and Sadoshima, J. 2007. Thioredoxin1 as a negative regulator of cardiac hypertrophy. Antioxid
Redox Signal 9:679-687.
108. Alcendor, R.R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S.F., and
Sadoshima, J. 2007. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 100:1512-1521.
107. Hirotani, S., Zhai, P., Tomita, H., Galeotti, J., Marquez, J.P., Gao, S., Hong, C., Yatani, A., Avila, J., and
Sadoshima, J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 101:1164-
1174.
106. Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., and Sadoshima, J. 2007.
Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and
Beclin 1 in mediating autophagy. Circ Res 100:914-922.
105. Morisco, C., Marrone, C., Trimarco, V., Crispo, S., Monti, M.G., Sadoshima, J., and Trimarco, B. 2007. Insulin
resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1
expression. Cardiovasc Res 76:453-464.
104. Nishizawa, T., Shen, Y.T., Rossi, F., Hong, C., Robbins, J., Ishikawa, Y., Sadoshima, J., Vatner, D.E., and
Vatner, S.F. 2007. Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha. Am
J Physiol Heart Circ Physiol 292:H971-975.
103. Odashima, M., Usui, S., Takagi, H., Hong, C., Liu, J., Yokota, M., and Sadoshima, J. 2007. Inhibition of
endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial
infarction. Circ Res 100:1344-1352.
102. Ohtsubo, H., Ichiki, T., Miyazaki, R., Inanaga, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa,
K. 2007. Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell. Arterioscler Thromb Vasc Biol
27:1549-1555.
101. Peter, P.S., Brady, J.E., Yan, L., Chen, W., Engelhardt, S., Wang, Y., Sadoshima, J., Vatner, S.F., and Vatner,
D.E. 2007. Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic
receptor, but not beta 1-adrenergic receptor. J Clin Invest 117:1335-1343.]
100. Takagi, H., Matsui, Y., Hirotani, S., Sakoda, H., Asano, T., and Sadoshima, J. 2007. AMPK mediates
autophagy during myocardial ischemia in vivo. Autophagy 3:405-407.
99. Takagi, H., Matsui, Y., and Sadoshima, J. 2007. The role of autophagy in mediating cell survival and death
during ischemia and reperfusion in the heart. Antioxid Redox Signal 9:1373-1381.
98. Yan, L., Vatner, D.E., O'Connor, J.P., Ivessa, A., Ge, H., Chen, W., Hirotani, S., Ishikawa, Y., Sadoshima, J.,
and Vatner, S.F. 2007. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130:
247-258.
97. Zhai, P., Gao, S., Holle, E., Yu, X., Yatani, A., Wagner, T., and Sadoshima, J. 2007. Glycogen synthase kinase-
3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-
regulated kinases. J Biol Chem 282:33181-33191.
2006
96. Ago, T., and Sadoshima, J. 2006. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res 98:294-
297.
95. Ago, T., and Sadoshima, J. 2006. Thioredoxin and ventricular remodeling. J Mol Cell Cardiol 41:762-773.
94. Ago, T., Yeh, I., Yamamoto, M., Schinke-Braun, M., Brown, J.A., Tian, B., and Sadoshima, J. 2006.
Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart.
Antioxid Redox Signal 8:1635-1650.
93. Chen, I.Y., Lypowy, J., Pain, J., Sayed, D., Grinberg, S., Alcendor, R.R., Sadoshima, J., and Abdellatif, M. 2006.
Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha. J Biol
Chem 281:19369-19377.
92. Depre, C., Wang, Q., Yan, L., Hedhli, N., Peter, P., Chen, L., Hong, C., Hittinger, L., Ghaleh, B., Sadoshima, J.,
Vatner, D.E., Vatner, S.F., and Madura, K. 2006. Activation of the cardiac proteasome during pressure overload
promotes ventricular hypertrophy. Circulation 114:1821-1828.
91. Liu, J., Sadoshima, J., Zhai, P., Hong, C., Yang, G., Chen, W., Yan, L., Wang, Y., Vatner, S.F., and Vatner, D.
E. 2006. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition. J
Mol Cell Cardiol 41:680-688.
90. Nishizawa, T., Vatner, S.F., Hong, C., Shen, Y.T., Hardt, S.E., Robbins, J., Ishikawa, Y., Sadoshima, J., and
Vatner, D.E. 2006. Overexpressed cardiac Gsalpha in rabbits. J Mol Cell Cardiol 41:44-50.
89. Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J.
T., Puigserver, P., Sadoshima, J., Deng, H., Pedrini, S., Gandy, S., Sauve, A.A., and Pasinetti, G.M. 2006. Neuronal
SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by
calorie restriction. J Biol Chem 281:21745-21754.
88. Sadoshima, J. 2006. Redox regulation of growth and death in cardiac myocytes. Antioxid Redox Signal 8:1621-
1624.
87. Usui, S., Yeh, I., Tian, B., and Sadoshima, J. 2006. Global changes in gene expression during cardiac
hypertrophy: a new direction of cardiac signaling research. J Mol Cell Cardiol 41:219-222.
86. Yan, L., Sadoshima, J., Vatner, D.E., and Vatner, S.F. 2006. Autophagy: a novel protective mechanism in
chronic ischemia. Cell Cycle 5:1175-1177.
85. Zebrowski, D.C., Alcendor, R.R., Kirshenbaum, L.A., and Sadoshima, J. 2006. Caspase-3 mediated cleavage
of MEKK1 promotes p53 transcriptional activity. J Mol Cell Cardiol 40:605-618.
84. Zhai, P., Galeotti, J., Liu, J., Holle, E., Yu, X., Wagner, T., and Sadoshima, J. 2006. An angiotensin II type 1
receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated
cardiac hypertrophy. Circ Res 99:528-536.
83. Zhai P, Galeotti J, Sadoshima J. 2006. Unconventional signaling mechanisms mediated by the angiotensin II
type I receptor in cardiovascular cell types. High Blood Pressure and Cardiovasc Prevention: 13, 143-150.
2005
82. Ding, B., Abe, J., Wei, H., Huang, Q., Walsh, R.A., Molina, C.A., Zhao, A., Sadoshima, J., Blaxall, B.C., Berk, B.
C., and Yan, C. 2005. Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.
Circulation 111:2469-2476.
81. Ding, B., Abe, J., Wei, H., Xu, H., Che, W., Aizawa, T., Liu, W., Molina, C.A., Sadoshima, J., Blaxall, B.C., Berk,
B.C., and Yan, C. 2005. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor
(ICER) leads to cardiomyocyte apoptosis. Proc Natl Acad Sci U S A 102:14771-14776.
80. Hase, M., Depre, C., Vatner, S.F., and Sadoshima, J. 2005. H11 has dose-dependent and dual hypertrophic
and proapoptotic functions in cardiac myocytes. Biochem J 388:475-483.
79. Hirotani, S., and Sadoshima, J. 2005. Preconditioning effects of PKCdelta. J Mol Cell Cardiol 39:719-721.
78. Morisco, C., Condorelli, G., Trimarco, V., Bellis, A., Marrone, C., Condorelli, G., Sadoshima, J., and Trimarco,
B. 2005. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ
Res 96:180-188.
77. Ono, H., Ichiki, T., Ohtsubo, H., Fukuyama, K., Imayama, I., Hashiguchi, Y., Sadoshima, J., and Sunagawa, K.
2005. Critical role of Mst1 in vascular remodeling after injury. Arterioscler Thromb Vasc Biol 25:1871-1876.
76. Yan, L., Vatner, D.E., Kim, S.J., Ge, H., Masurekar, M., Massover, W.H., Yang, G., Matsui, Y., Sadoshima, J.,
and Vatner, S.F. 2005. Autophagy in chronically ischemic myocardium. Proc Natl Acad Sci U S A 102:13807-13812.
75. Zhai, P., Yamamoto, M., Galeotti, J., Liu, J., Masurekar, M., Thaisz, J., Irie, K., Holle, E., Yu, X., Kupershmidt, S.,
Roden, D.M., Wagner, T., Yatani, A., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2005. Cardiac-specific
overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in
transgenic mice. J Clin Invest 115:3045-3056.
2004
74. Alcendor, R.R., Kirshenbaum, L.A., Imai, S., Vatner, S.F., and Sadoshima, J. 2004. Silent information regulator
2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac
myocytes. Circ Res 95:971-980.
73. Hardt, S.E., and Sadoshima, J. 2004. Negative regulators of cardiac hypertrophy. Cardiovasc Res 63:500-509.
72. Hardt, S.E., Tomita, H., Katus, H.A., and Sadoshima, J. 2004. Phosphorylation of eukaryotic translation
initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.
Circ Res 94:926-935.
71. Karoor, V., Vatner, S.F., Takagi, G., Yang, G., Thaisz, J., Sadoshima, J., and Vatner, D.E. 2004. Propranolol
prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart
failure. J Mol Cell Cardiol 36:305-312.
70. Kawabe, J., Okumura, S., Lee, M.C., Sadoshima, J., and Ishikawa, Y. 2004. Translocation of caveolin regulates
stretch-induced ERK activity in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 286:H1845-1852.
69. Kim, T.G., Chen, J., Sadoshima, J., and Lee, Y. 2004. Jumonji represses atrial natriuretic factor gene
expression by inhibiting transcriptional activities of cardiac transcription factors. Mol Cell Biol 24:10151-10160.
68. Matsui, Y., and Sadoshima, J. 2004. Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli:
implication for cardiac fibrosis and hypertrophy. J Mol Cell Cardiol 37:477-481.
2003
67. Kim, S.J., Peppas, A., Hong, S.K., Yang, G., Huang, Y., Diaz, G., Sadoshima, J., Vatner, D.E., and Vatner, S.F.
2003. Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms. Circ
Res 92:1233-1239.
65. Kim, Y.K., Kim, S.J., Yatani, A., Huang, Y., Castelli, G., Vatner, D.E., Liu, J., Zhang, Q., Diaz, G., Zieba, R.,
Thaisz, J., Drusco, A., Croce, C., Sadoshima, J., Condorelli, G., and Vatner, S.F. 2003. Mechanism of enhanced
cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem 278:47622-47628.
65. Li, J., Yatani, A., Kim, S.J., Takagi, G., Irie, K., Zhang, Q., Karoor, V., Hong, C., Yang, G., Sadoshima, J.,
Depre, C., Vatner, D.E., West, M.J., and Vatner, S.F. 2003. Neurally-mediated increase in calcineurin activity regulates
cardiac contractile function in absence of hypertrophy. Cardiovasc Res 59:649-657.
43. Morisco, C., Sadoshima, J., Trimarco, B., Arora, R., Vatner, D.E., and Vatner, S.F. 2003. Is treating cardiac
hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol Heart Circ Physiol 284:H1043-1047.
63. Okumura, S., Kawabe, J., Yatani, A., Takagi, G., Lee, M.C., Hong, C., Liu, J., Takagi, I., Sadoshima, J., Vatner,
D.E., Vatner, S.F., and Ishikawa, Y. 2003. Type 5 adenylyl cyclase disruption alters not only sympathetic but also
parasympathetic and calcium-mediated cardiac regulation. Circ Res 93:364-371.
62. Okumura, S., Takagi, G., Kawabe, J., Yang, G., Lee, M.C., Hong, C., Liu, J., Vatner, D.E., Sadoshima, J.,
Vatner, S.F., and Ishikawa, Y. 2003. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against
pressure overload. Proc Natl Acad Sci U S A 100:9986-9990.
61. Seta, K., and Sadoshima, J. 2003. Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor
mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor. J Biol Chem 278:9019-9026.
60. Tomita, H., Nazmy, M., Kajimoto, K., Yehia, G., Molina, C.A., and Sadoshima, J. 2003. Inducible cAMP early
repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac
myocyte apoptosis in response to beta-adrenergic receptor stimulation. Circ Res 93:12-22.
59. Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T., Vatner, S.F., and Sadoshima, J. 2003.
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy. J Clin Invest 112:
1395-1406.
58. Yamamoto, S., Yang, G., Zablocki, D., Liu, J., Hong, C., Kim, S.J., Soler, S., Odashima, M., Thaisz, J., Yehia,
G., Molina, C.A., Yatani, A., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2003. Activation of Mst1 causes dilated
cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy. J Clin Invest 111:
1463-1474.
2002
57. Condorelli, G., Drusco, A., Stassi, G., Bellacosa, A., Roncarati, R., Iaccarino, G., Russo, M.A., Gu, Y., Dalton,
N., Chung, C., Latronico, M.V., Napoli, C., Sadoshima, J., Croce, C.M., and Ross, J., Jr. 2002. Akt induces enhanced
myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A 99:12333-12338.
56. Depre, C., Hase, M., Gaussin, V., Zajac, A., Wang, L., Hittinger, L., Ghaleh, B., Yu, X., Kudej, R.K., Wagner, T.,
Sadoshima, J., and Vatner, S.F. 2002. H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circ Res 91:
1007-1014.
54. Hardt, S.E., and Sadoshima, J. 2002. Glycogen synthase kinase-3beta: a novel regulator of cardiac
hypertrophy and development. Circ Res 90:1055-1063.
54. Sadoshima, J. 2002. Novel AT(1) receptor-independent functions of losartan. Circ Res 90:754-756.
53. Sadoshima, J., Montagne, O., Wang, Q., Yang, G., Warden, J., Liu, J., Takagi, G., Karoor, V., Hong, C.,
Johnson, G.L., Vatner, D.E., and Vatner, S.F. 2002. The MEKK1-JNK pathway plays a protective role in pressure
overload but does not mediate cardiac hypertrophy. J Clin Invest 110:271-279.
52. Seta, K., Nanamori, M., Modrall, J.G., Neubig, R.R., and Sadoshima, J. 2002. AT1 receptor mutant lacking
heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs. J Biol
Chem 277:9268-9277.
51. Seta, K., and Sadoshima, J. 2002. What is the unique function of SAPK3/p38gamma in cardiac myocytes? J
Mol Cell Cardiol 34:597-600.
2001
50. Modrall, J.G., Nanamori, M., Sadoshima, J., Barnhart, D.C., Stanley, J.C., and Neubig, R.R. 2001. ANG II type 1
receptor downregulation does not require receptor endocytosis or G protein coupling. Am J Physiol Cell Physiol 281:
C801-809.
49. Morisco, C., Seta, K., Hardt, S.E., Lee, Y., Vatner, S.F., and Sadoshima, J. 2001. Glycogen synthase kinase
3beta regulates GATA4 in cardiac myocytes. J Biol Chem 276:28586-28597.
48. Morisco, C., Zebrowski, D.C., Vatner, D.E., Vatner, S.F., and Sadoshima, J. 2001. Beta-adrenergic cardiac
hypertrophy is mediated primarily by the beta(1)-subtype in the rat heart. J Mol Cell Cardiol 33:561-573.
47. Yamamoto, S., Seta, K., Morisco, C., Vatner, S.F., and Sadoshima, J. 2001. Chelerythrine rapidly induces
apoptosis through generation of reactive oxygen species in cardiac myocytes. J Mol Cell Cardiol 33:1829-1848.
46. Yang, G., Meguro, T., Hong, C., Asai, K., Takagi, G., Karoor, V.L., Sadoshima, J., Vatner, D.E., Bishop, S.P.,
and Vatner, S.F. 2001. Cyclosporine reduces left ventricular mass with chronic aortic banding in mice, which could be
due to apoptosis and fibrosis. J Mol Cell Cardiol 33:1505-1514.
2000
45. Aoki, H., Richmond, M., Izumo, S., and Sadoshima, J. 2000. Specific role of the extracellular signal-regulated
kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. Biochem J 347 Pt 1:275-284.
44. Aoki, H., Sadoshima, J., and Izumo, S. 2000. Myosin light chain kinase mediates sarcomere organization during
cardiac hypertrophy in vitro. Nat Med 6:183-188.
43. Babu, G.J., Lalli, M.J., Sussman, M.A., Sadoshima, J., and Periasamy, M. 2000. Phosphorylation of elk-1 by
MEK/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy. J Mol Cell Cardiol 32:
1447-1457.
42. Morisco, C., Zebrowski, D., Condorelli, G., Tsichlis, P., Vatner, S.F., and Sadoshima, J. 2000. The Akt-glycogen
synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor
stimulation in cardiac myocytes. J Biol Chem 275:14466-14475.
41. Sadoshima, J. 2000. Cytokine actions of angiotensin II. Circ Res 86:1187-1189.
1999
40. Malhotra, R., Sadoshima, J., Brosius, F.C., 3rd, and Izumo, S. 1999. Mechanical stretch and angiotensin II
differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circ Res 85:137-146.
39. Yamamoto, M., Okumura, S., Schwencke, C., Sadoshima, J., and Ishikawa, Y. 1999. High efficiency gene
transfer by multiple transfection protocol. Histochem J 31:241-243.
1998
38. Aoki, H., Izumo, S., and Sadoshima, J. 1998. Angiotensin II activates RhoA in cardiac myocytes: a critical role of
RhoA in angiotensin II-induced premyofibril formation. Circ Res 82:666-676.
37. Sadoshima, J. 1998. Versatility of the angiotensin II type 1 receptor. Circ Res 82:1352-1355.
1997
36. Sadoshima, J., Aoki, H., and Izumo, S. 1997. Angiotensin II and serum differentially regulate expression of
cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac
myocytes. Circ Res 80:228-241.
35. Sadoshima, J., and Izumo, S. 1997. The cellular and molecular response of cardiac myocytes to mechanical
stress. Annu Rev Physiol 59:551-571.
34. Sadoshima, J., and Izumo, S. 1997. Tyrosine kinases mediation of c-fos expression by cell swelling in cardiac
myocytes. Heart Vessels Suppl 12:194-197.
33. Todisco, A., Takeuchi, Y., Yamada, J., Sadoshima, J.I., and Yamada, T. 1997. Molecular mechanisms for
somatostatin inhibition of c-fos gene expression. Am J Physiol 272:G721-726.
1996
32. Jahn, L., Sadoshima, J., Greene, A., Parker, C., Morgan, K.G., and Izumo, S. 1996. Conditional differentiation
of heart- and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. J Cell Sci
109 ( Pt 2):397-407.
31. Sadoshima, J., and Izumo, S. 1996. Autocrine secretion of angiotensin II mediates stretch-induced hypertrophy
of cardiac myocytes in vitro. Contrib Nephrol 118:214-221.
30. Sadoshima, J., and Izumo, S. 1996. The heterotrimeric G q protein-coupled angiotensin II receptor activates
p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. Embo J 15:775-787.
29. Sadoshima, J., Malhotra, R., and Izumo, S. 1996. The role of the cardiac renin-angiotensin system in load-
induced cardiac hypertrophy. J Card Fail 2:S1-6.
28. Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1996. Tyrosine kinase activation is an immediate and
essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes. Embo J
15:5535-5546.
1995
27. Sadoshima, J., and Izumo, S. 1995. Rapamycin selectively inhibits angiotensin II-induced increase in protein
synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy.
Circ Res 77:1040-1052.
26. Sadoshima, J., Qiu, Z., Morgan, J.P., and Izumo, S. 1995. Angiotensin II and other hypertrophic stimuli
mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6
kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circ Res 76:1-15.
25. Schunkert, H., Sadoshima, J., Cornelius, T., Kagaya, Y., Weinberg, E.O., Izumo, S., Riegger, G., and Lorell, B.
H. 1995. Angiotensin II-induced growth responses in isolated adult rat hearts. Evidence for load-independent induction
of cardiac protein synthesis by angiotensin II. Circ Res 76:489-497.
1994
24. Jahn, L., Sadoshima, J., and Izumo, S. 1994. Cyclins and cyclin-dependent kinases are differentially regulated
during terminal differentiation of C2C12 muscle cells. Exp Cell Res 212:297-307.
23. Kai, H., Koyanagi, S., Hirooka, Y., Sugimachi, M., Sadoshima, J., Suzuki, S., and Takeshita, A. 1994. Right-to-
left shunt across atrial septal defect related to tricuspid regurgitation: assessment by transesophageal Doppler
echocardiography. Am Heart J 127:578-584.
1993
22. Sadoshima, J., and Izumo, S. 1993. Mechanotransduction in stretch-induced hypertrophy of cardiac myocytes.
J Recept Res 13:777-794.
21. Sadoshima, J., and Izumo, S. 1993. Mechanical stretch rapidly activates multiple signal transduction pathways
in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. Embo J 12:1681-1692.
20. Sadoshima, J., and Izumo, S. 1993. Molecular characterization of angiotensin II--induced hypertrophy of
cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res 73:413-423.
19. Sadoshima, J., and Izumo, S. 1993. Signal transduction pathways of angiotensin II--induced c-fos gene
expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers. Circ Res 73:424-438.
18. Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-
induced hypertrophy of cardiac myocytes in vitro. Cell 75:977-984.
1992
17. Sadoshima, J., Jahn, L., Takahashi, T., Kulik, T.J., and Izumo, S. 1992. Molecular characterization of the
stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy. J Biol Chem
267:10551-10560.
16. Sadoshima, J., Koyanagi, S., Sugimachi, M., Hirooka, Y., and Takeshita, A. 1992. Evaluation of the severity of
mitral regurgitation by transesophageal Doppler flow echocardiography. Am Heart J 123:1245-1251.
15. Sadoshima, J., Takahashi, T., Jahn, L., and Izumo, S. 1992. Roles of mechano-sensitive ion channels,
cytoskeleton, and contractile activity in stretch-induced immediate-early gene expression and hypertrophy of cardiac
myocytes. Proc Natl Acad Sci U S A 89:9905-9909.
1991
14. Lai, C.P., Koyanagi, S., Sadoshima, J., Takeshita, A., and Tokunaga, K. 1991. Transesophageal
echocardiographic findings of quadricuspid aortic valve. Jpn Heart J 32:731-734.
13. Sadoshima, J., and Akaike, N. 1991. Kinetic properties of the caffeine-induced transient outward current in bull-
frog sympathetic neurones. J Physiol 433:341-355.
1990
12. Kuga, T., Sadoshima, J., Tomoike, H., Kanaide, H., Akaike, N., and Nakamura, M. 1990. Actions of Ca2+
antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture. Circ Res 67:469-480.
11. Sadoshima, J., Oyama, Y., and Akaike, N. 1990. Inhibition of nicotinic acetylcholine response by atropine in
frog isolated sympathetic neurons. Brain Res 508:147-151.
1989
10. Akaike, N., Kanaide, H., Kuga, T., Nakamura, M., Sadoshima, J., and Tomoike, H. 1989. Low-voltage-activated
calcium current in rat aorta smooth muscle cells in primary culture. J Physiol 416:141-160.
9. Akaike, N., and Sadoshima, J. 1989. Caffeine affects four different ionic currents in the bull-frog sympathetic
neurone. J Physiol 412:221-244.
8. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1989. Voltage-dependent anion-
selective channels in cultured smooth muscle cells of the rat aorta. Comp Biochem Physiol A Comp Physiol 92:61-63.
1988
7. Oyama, Y., Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Some properties of inhibitory action of lidocaine
on the Ca2+ current of single isolated frog sensory neurons. Brain Res 442:223-228.
6. Sadoshima, J., Akaike, N., Kanaide, H., and Nakamura, M. 1988. Cyclic AMP modulates Ca-activated K channel
in cultured smooth muscle cells of rat aortas. Am J Physiol 255:H754-759.
5. Sadoshima, J., Akaike, N., Tomoike, H., Kanaide, H., and Nakamura, M. 1988. Ca-activated K channel in
cultured smooth muscle cells of rat aortic media. Am J Physiol 255:H410-418.
4. Sadoshima, J., Tokutomi, N., and Akaike, N. 1988. Effects of neostigmine and physostigmine on the
acetylcholine receptor-ionophore complex in frog isolated sympathetic neurones. Br J Pharmacol 94:620-624.
1987
3. Inoue, M., Sadoshima, J., and Akaike, N. 1987. Different actions of intracellular free calcium on resting and
GABA-gated chloride conductances. Brain Res 404:301-303.
2. Sadoshima, J., Nakashima, Y., Taira, Y., Koyanagi, S., Takeshita, A., Tanaka, K., and Nakamura, M. 1987. A
case of primary dissecting aneurysm of the coronary artery. Jpn Heart J 28:799-804.
1. Sadoshima, J., Taira, Y., Shimokawa, H., Koyanagi, S., Takeshita, A., and Nakamura, M. 1987. Two cases of
dilated cardiomyopathy complicated by left ventricular aneurysm. Chest 92:377-379.
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Publications